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early traditional chinese medicine bundle therapy for the prevention of sepsis acute gastrointestinal injury in elderly patients with severe sepsis

by:Xilong      2019-09-23
The purpose of this study is to study the effect of early Chinese medicine binding therapy on the prevention of sepsis
Related Acute intestinal injury (AGI).
This is a multi-center, forward-looking, observational, non-
Randomized cohort study of 296 consecutive patients with severe sepsis during 2013/3 and 2014/11
150 patients receiving standard treatment (controls)
And 146 received bundled treatment with traditional Chinese medicine (
Intervention Group)(
Chinese medicine decoction, Chinese medicine acupuncture, mirabilite application, defecation mixture). D-
L-lactic acid, diamino-enzyme, endotoxin, gas, gastric actin and internal
Measure abdominal pressure.
AGI is divided into four levels.
Compared to the control, D-
Lactic acid, diammonium oxide, endotoxin, gas and internal
The abdominal pressure in the intervention group decreased, and the stomach movement increased in 7 days.
Intervention Group of AGI incidence group was lower than that in the control group.
GIF scores in the intervention agi ii and III groups were lower than those in the control group.
The apache ii scores in the intervention agi ii, III and IV groups were lower than those in the control group.
Compared with the control group, the mechanical ventilation time and ICU stay in the intervention group were shorter, 28-
Sky whole and Echo
The mortality rate is low.
For elderly patients with severe sepsis, early Chinese medicine binding treatment can reduce the incidence of AGI and improve the prognosis.
This is a forward-looking, observational, non-
A randomized, multi-center study of 551 patients with severe sepsis treated in icu of Zhejiang Provincial Hospital of Traditional Chinese Medicine, Tongde Hospital of Zhejiang province, Xinhua Hospital of Zhejiang province, March 2013 and November 2014 Hangzhou Hospital of Traditional Chinese Medicine.
Each ethics committee involved in the hospital approved the research programme.
The legal representative of the patient signed an informed consent form.
All procedures are implemented in accordance with relevant guidelines and regulations.
The study is registered in the Chinese clinical trial registry (
Registration number: ChiCTR-IOR-15007625;
Registration Date: 2015-11-18;
Available online :).
All patients were diagnosed with severe sepsis according to the diagnostic criteria of the international guide for the management of severe sepsis and septic shock 2012.
Patients must meet any of the following criteria with organ dysfunction and/or tissue perfusion caused by sepsis: 1)
Low pressure caused by sepsis; 2)
The level of lactic acid above normal; 3)
Although adequate fluid recovery was given, the amount of urine was still
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